FT-Alz

Chemical Name: 5-(2,6-Dideoxy-2-fluoro-alpha-L-talopyranosyloxy)-6-hydroxynaphtho[2,3-f]quinoline-7,12-dione
项目整合开发状态: Preclinical
项目研究机构: Institute of Bioorganic Chemistry (Originator), Keio University (Originator)
合成路线:Coupling of alizarin blue (I) with the pyranosyl bromide (II) under Koenigs-Knorr conditions in the presence of HgO and HgBr2 afforded the target 5-talopyranoside derivative (III) along with minor amounts of the 5,6-bis-talopyranoside,which were separated by preparative thin layer chromatography.Deacetylation of (III) using NaOMe in MeOH-THF then gave the title compound.