新产品编号:1786587

Chemical Name: N-[2-[2-[1-(Methoxyoxalyl)-L-prolyl-D-phenylalanylamido]phenoxy]acetyl]-O-sulfo-L-tyrosyl-L-aspartyl-L-isoleucyl-L-asparaginyl-O-sulfo-L-tyrosyl-O-sulfo-L-tyrosyl-O-sulfo-L-threonyl-O-sulfo-L-seryl-L-glutamic acid pentakis(triethylammonium) salt
项目整合开发状态: Biological Testing
项目研究机构: Gunma University (Originator), University of Shizuoka (Originator)
合成路线:Cleavage of the Boc group from the protected peptide (I) by means of HCl in dioxan gave (II).To this was coupled the carboxylic acid (III) using EDC and HOBt to afford the corresponding amide (IV).

合成路线:Hydrogenolysis of the benzyl protecting groups provided (V).The desired pentasulfate analogue was obtained by treatment of (V) with SO3 in pyridine,followed by formation of the triethylamine salt.