新产品编号:1783423

Chemical Name: N2-[trans-4-(Aminomethyl)cyclohexylcarbonyl]-N1-octyl-O-(2-bromobenzyloxycarbonyl)-L-tyrosinamide hydrochloride
项目整合开发状态: Biological Testing
项目研究机构: Kobe Gakuin University (Originator), Kobe University (Originator)
合成路线:Activation of O-(2-bromobenzyloxycarbonyl)-N-Boc-L-tyrosine (I) as the mixed anhydride (II) with isobutyl chloroformate,followed by coupling with n-octylamine (III),furnished amide (IV).The Boc protecting group of (IV) was then removed by treatment with HCl in dioxan to give amine (V).After activation of trans-4-(aminomethyl)cyclohexanecarboxylic acid (VI) as the mixed anhydride (VII),its coupling with amine (V) provided adduct (VIII).Finally,the cleavage of the Boc protecting group of (VIII) by means of HCl in dioxan yielded the title compound.