新产品编号:1773931

Chemical Name: 5-[3-(Dimethylamino)propoxy]-4-methyl-2H-[1]benzofuro[2,3-h][1]benzopyran-2-one
项目整合开发状态: Biological Testing
项目研究机构: Universidad de Santiago de Compostela (Originator), Universit?degli Studi di Padova (Originator)
合成路线:Condensation of 7-hydroxy-5-methoxy-4-methylcoumarin (I) with 2-chlorocyclohexanone (II) by means of K2CO3 in refluxing acetone affords derivative (III),which is then cyclized by means of refluxing NaOH to provide compound (IV).Oxidation of (IV) by means of DDQ in refluxing benzene furnishes angelicine (V),whose methoxy group is then hydrolyzed with HI and acetic anhydride in refluxing HOAc to yield compound (VI).Finally,the desired product is obtained by coupling of (VI) with 3-chloro-N,N'-dimethylpropylamine (VII) by means of Williamson's reaction using NaH and NaI in refluxing DMF or using K2CO3 and HMPA in refluxing acetone.