S-44

Chemical Name: 5-Bromo-1-(1-piperidinylmethyl)-3-[3-(4-pyridyl)-5-sulfanyl-4H-1,2,4-triazol-4-ylimino]-2,3-dihydro-1H-indol-2-one
项目整合开发状态: Biological Testing
项目研究机构: Banaras Hindu University (Originator), Rega Institute for Medical Research (Originator)
合成路线:Isoniazid (I) was treated with carbon disulfide and KOH to give potassium 4-pyridyl dithiocarbazinate (II).Cyclization of (II) in the presence of hydrazine produced the amino triazole (III).This was condensed with 5-bromoisatin (IV),yielding the imino adduct (V).Finally,Mannich reaction of (V) with piperidine (VI) and formaldehyde furnished the title compound.