新产品编号:1767603

Chemical Name: 3,7,11,15-Tetraazaheptadecane-5(R),13(R)-diol tetrahydrochloride
项目整合开发状态: Preclinical
项目研究机构: University of Florida (Originator)
合成路线:Alkylation of N-ethyl p-toluenesulfonamide (I) with (S)-4-(chloromethyl)-2,2-dimethyl-1,3-dioxolane (II) afforded the N,N-dialkylated tosylamide (III).Deprotection of ketal (III),followed by selective mono tosylation of the resulting diol (IV),yielded (V),which was cyclized to epoxide (VI) upon treatment with K2CO3 in MeOH.Epoxide ring opening with N,N'-dibenzyl-1,3-diaminopropane (VII) gave the fully protected tetraamine (VIII).Removal of the p-toluenesulfonyl groups of (VIII) was accomplished using sodium naphthalenide providing (IX).Finally,hydrogenolytic debenzylation of (IX) furnished the title tetraamine.