新产品编号:1766021
Chemical Name: 2-(Acetoxymethoxy)-1-(1-pyrrolidinyl)diazen-1-ium-1-olate
项目整合开发状态: Biological Testing
项目研究机构: National Cancer Institute (Originator)
合成路线:Exposure of pyrrolidine (I) to NO in acetonitrile/ether in the presence of NaOMe in MeOH provides sodium 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (II),which is converted into the desired product by reaction with bromomethyl acetate (III) in DMSO in the presence of Na2CO3 and silver acetate (HgOAc).
📌 参考资料/链接：
参考文献标题:Targeting nitric oxide (NO) delivery in vivo.Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver
文献作者:Saavedra,J.E.; Billiar,T.R.; Williams,D.L.; Kim,Y.M.; Watkins,S.C.; Keefer,L.K.
参考来源:J Med Chem 1997,40(13),1947
📄 详细内容
合成路线:Exposure of pyrrolidine (I) to NO in acetonitrile/ether in the presence of NaOMe in MeOH provides sodium 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (II),which is converted into the desired product by reaction with bromomethyl acetate (III) in DMSO in the presence of Na2CO3 and silver acetate (HgOAc).
参考文献标题:Esterase-sensitive nitric oxide donors of the diazeniumdiolate family: In vitro antileukemic activity
文献作者:Saavedra,J.E.; Shami,P.J.; Wang,L.Y.; Davies,K.M.; Booth,M.N.; Citro,M.L.; Keefer,L.K.
参考来源:J Med Chem 2000,43(2),261