新产品编号:1734381
Chemical Name: N1-[3-Benzoyl-4-(2-phenylacetamido)phenyl]-L-cysteinamide hydrochloride
项目整合开发状态: Biological Testing
项目研究机构: Philipps-Universit鋞 Marburg (Originator)
合成路线:Acylation of 2-amino-5-nitrobenzophenone (I) with phenylacetic acid chloride (II) in refluxing toluene yields derivative (III),whose nitro group is reduced by means of SnCl2 in refluxing EtOAc to afford amine (IV).Coupling of (IV) with protected cysteine (V) by means of isobutyl chloroformate and N-methylmorpholine (NMM) in DMF provides protected derivative (VI),which is finally treated with TFA and Et3SiH in CH2Cl2 to furnish the target compound.
📌 参考资料/链接：
参考文献标题:Cysteine amides as farnesyl transferase inhibitors
文献作者:Grabley,S.; Thiericke,R.; Sattler,I.(Hans Kn鰈l Institute for Natural Product Research)
参考来源:DE 19851714; WO 0027803
📄 详细内容
合成路线:Acylation of 2-amino-5-nitrobenzophenone (I) with phenylacetic acid chloride (II) in refluxing toluene yields derivative (III),whose nitro group is reduced by means of SnCl2 in refluxing EtOAc to afford amine (IV).Coupling of (IV) with protected cysteine (V) by means of isobutyl chloroformate and N-methylmorpholine (NMM) in DMF provides protected derivative (VI),which is finally treated with TFA and Et3SiH in CH2Cl2 to furnish the target compound.
参考文献标题:Different amino acid replacement in CAAX-tetrapeptide based peptidomimetic farnesyltransferase inhibitors
文献作者:Schlitzer,M.; et al.
参考来源:Archiv der Pharmazie 1999,332(4),124