新产品编号:1728053

Chemical Name: 2-(6-Chloro-2-oxo-2H-1-benzopyran-3-ylcarboxamido)benzoic acid
项目整合开发状态: Preclinical
项目研究机构: Ukrainian Academy of Pharmacy (Originator)
合成路线:By cyclization of 2-hydroxybenzaldehyde (I) with 4-(cyanacetamido)benzoic acid ethyl ester (II) catalyzed by piperidine in ethanol.

合成路线:The cyclization of 2-hydroxybenzaldehyde (I) with 2-(cyanacetamido)benzoic acid methyl ester (II) catalyzed by piperidine in ethanol gives the 2-imino-1-benzopyran (III),which is then hydrolyzed to the target benzopyranone with HCl in refluxing ethanol/water.

合成路线:The cyclization of 2-hydroxybenzaldehyde (I) with 4-(cyanacetamido)benzoic acid ethyl ester (II) catalyzed by piperidine in ethanol gives the 2-imino-1-benzopyran (III),which is then hydrolyzed to the target benzopyranone with HCl in refluxing ethanol/water.

合成路线:By cyclization of 5-chloro-2-hydroxybenzaldehyde (I) with N-(2-carboxyphenyl) malonamic acid ethyl ester (II) catalyzed by piperidine in ethanol.