PT-653
Chemical Name: 6-(5H-Dibenzo[b,f]azepin-5-ylmethyl)-2,4-pteridinediamine
项目整合开发状态: Biological Testing
项目研究机构: Harvard Medical School (Originator), Indiana University (Originator)
合成路线:Title compound is obtained by condensation of 6-(bromomethyl)pteridine-2,4-diamine (I) with dibenz[b,f]azepine (II) by means of NaH in THF..
📌 参考资料/链接：
参考文献标题:Pharmaceutically active cpds.and methods of use thereof
文献作者:Rosowsky,A.(Dana-Farber Cancer Institute)
参考来源:WO 0059884
📄 详细内容
合成路线:Title compound is obtained by condensation of 6-(bromomethyl)pteridine-2,4-diamine (I) with dibenz[b,f]azepine (II) by means of NaH in THF..
参考文献标题:Structure-based design of selective inhibitors of dihydrofolate reductase: Synthesis and antiparasitic activity of 2,4-diaminopteridine analogues with a bridged diarylamine side chain
文献作者:Rosowsky,A.; Cody,V.; Galitsky,N.; Fu,H.; Papoulis,A.T.; Queener,S.F.
参考来源:J Med Chem 1999,42(23),4853