新产品编号:1710651

Chemical Name: 3-[(1R,4S,5R,8S,9R,12R,13R)-1,5,9-Trimethyl-10-oxo-14,15,16-trioxa-11-azatetracyclo[10.3.1.0(4,13).0(8,13)]hexadec-11-yl]prop-2(E)-enoic acid methyl ester; (3R,5aS,6R,8aS,9R,12R,12aR)-3-(3,6,9-Trimethyl-10-oxoperhydro-3,12-epoxy-1,2-dioxepino[4,3-i]isoqui
项目整合开发状态: Biological Testing
项目研究机构: National Institutes of Health (Originator), Walter Reed Army Institute (Originator)
合成路线:11-Azaartemisinin (II) was prepared from artemisinin (I) by reaction with methanolic ammonia,followed by acid treatment.Then,conjugate addition of methyl propiolate (III) to 11-azaartemisinin (II) in the presence of dimethylaminopyridine furnished the title compound.