新产品编号:1642625

Chemical Name: 2-(tert-Butylaminomethyl)-4-(7-chloro-4-quinolinylamino)-6-isopropylphenol
项目整合开发状态: Preclinical
项目研究机构: University of Liverpool (Originator)
合成路线:The reaction of 2-propylphenol (I) first with NaNO2/AcOH,then with Na2S2O4 and finally with acetic anhydride gives the acetamide (II),which is treated with formaldehyde and tert-butylamine in ethanol yielding the tert-butylaminomethyl derivative (III).The hydrolysis of (III) with 6M HCl affords the aminophenol (IV),which is finally condensed with 4,7-dichloroquinoline (V) in refluxing ethanol.

合成路线:The reaction of 2-isopropylphenol (I) first with NaNO2/AcOH,then with Na2S2O4 and finally with acetic anhydride gives the acetamide (II),which is treated with formaldehyde and tert-butylamine in ethanol yielding the tert-butylaminomethyl derivative (III).The hydrolysis of (III) with 6M HCl affords the aminophenol (IV),which is finally condensed with 4,7-dichloroquinoline (V) in refluxing ethanol.