新产品编号:1639461
Chemical Name: Decyl O-(2,3,4,6-tetra-O-sulfo-beta-D-glucopyranosyl)-(1--3)-O-(2,4,6-tri-O-sulfo-beta-D-glucopyranosyl)-(1--3)-O-(2,4,6-tri-O-sulfo-beta-D-glucopyranosyl)-(1--3)-O-(2,4,6-tri-O-sulfo-beta-D-glucopyranosyl)-(1--3)-2,4,6-tri-O-sulfo-beta-D-glucopyranoside
项目整合开发状态: Biological Testing
项目研究机构: University of Tokyo (Originator)
合成路线:Oligosaccharide (I) was peracetylated with Ac2O and KOAc,yielding ester (II).Condensation with decyl alcohol in the presence of SnCl4 produced glycoside (III),which was deacetylated with NaOMe in MeOH to give (IV).Sulfation was effected by means of sulfur trioxide-pyridine,followed by passage through an ion-exchange resin to furnish the corresponding sodium sulfate salt.
📌 参考资料/链接:
参考文献标题:Synthesis of sulfated oligosaccharide glycosides having high anti-HIV activity and the relationship between activity and chemical structure
文献作者:Katsuraya,K.; Nakashima,H.; Yamamoto,N.; Uryu,T.
参考来源:Carbohydr Res 1999,315(3-4),234