XR-3054

Chemical Name: cis-8-Isopropenyl-2,2-dimethyl-1,3-dioxaspiro[4.5]decane
项目整合开发状态: Preclinical
项目研究机构: Xenova (Originator)
合成路线:Sharpless asymmetric epoxidation of (S)-(-)-perillyl alcohol (I) using tert-butyl hydroperoxide and diethyl L-tartrate produced epoxide (II),which was reduced to diol (III) by means of LiAlH4 in cold THF.Treatment of (III) with 2,2-dimethoxypropane (IV) and p-toluenesulfonic acid then furnished the title isopropylidene ketal.