新产品编号:1612567

Chemical Name: N-[3(R)-Amino-2(S)-hydroxy-5-methylhexanoyl]-L-prolyl-L-alaninamide
项目整合开发状态: Biological Testing
项目研究机构: Pfizer (Originator)
合成路线:The compound was prepared by solid phase peptide synthesis on a p-methylbenzhydrylamine resin.Attachment of Boc-L-alanine (I) afforded resin (II).Subsequent deprotection of the Boc group of (II) gave the alanine-linked resin (III).Coupling of (III) with Boc-L-proline (IV),followed by Boc group cleavage yielded the dipeptide resin (V).Further coupling of (V) with N-Boc-(2S,3R)-3-amino-2-hydroxy-5-methylhexanoic acid (VI) furnished the tripeptide resin (VI).Finally,deprotection of the Boc group of (VI) and simultaneous cleavage from the resin by treatment with HF provided the title tripeptide amide.