GG-121
Chemical Name: 8-Chloro-3-(3-thienyl)pyrazolo[5,1-c][1,2,4]benzotriazine-5-oxide
项目整合开发状态: Preclinical
项目研究机构: Universit?degli Studi di Firenze (Originator), Universit?degli Studi di Pisa (Originator)
合成路线:Condensation of 2-nitro-5-chlorophenylhydrazine (I) with cyanoaldehyde (II) afforded the aminopyrazole derivative (III).This was then cyclized to the target benzotriazine system upon treatment with aqueous NaOH.
📌 参考资料/链接：
参考文献标题:Benzodiazepine receptor ligands.4.Synthesis and pharmacological evaluation of 3-heteroaryl-8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides
文献作者:Costanzo,A.; Guerrini,G.; Ciciani,G.; Bruni,F.; Selleri,S.; Costa,B.; Martini,C.; Lucacchini,A.; Aiello,P.M.; Ipponi,A.
参考来源:J Med Chem 1999,42(12),2218