LASSBio-341
Chemical Name: 5-[2-(4-Chlorophenyl)-8-methyl-6-phenyl-6H-pyrazolo[3,4-b]thieno[2,3-d]pyridin-3-yloxy]-5-oxopentanoic acid
项目整合开发状态: Preclinical
项目研究机构: LASSBio (Originator)
合成路线:Condensation of the known chloro pyrazolopyridine (I) with the lithium salt of 4-chlorobenzylthiol (II) produces the intermediate thioether (III) which,in the presence of excess LDA,undergoes intramolecular Claisen condensation to the pyrazolothienopyridine derivative (IV).Subsequent acylation of (IV) with glutaric anhydride (V) in acetone gives rise to the target glutarate mono-ester.
📌 参考资料/链接：
参考文献标题:Design,synthesis and pharmacological evaluation of novel pyrazolo[3,4-b]thieno[2,3-d]pyridine acid derivatives: A new class of anti-inflammatory and anti-platelet agents
文献作者:Cardoso,C.R.; de Brito,F.C.F.; da Silva,K.C.M.; de Miranda,A.L.P.; Fraga,C.A.M.; Barreiro,E.J.
参考来源:Bioorg Med Chem Lett 2002,12(1),9