9-Nitropaullone, Alsterpaullone, NSC-705701
Chemical Name: 9-Nitro-7,12-dihydroindolo[3,2-d]-1-benzazepin-6(5H)-one
项目整合开发状态: Preclinical
项目研究机构: CNRS (Originator), National Cancer Institute (Originator), Universit鋞 Hamburg (Originator)
合成路线:The condensation of p-nitrophenylhydrazine (I) with benzazepinedione (II) in AcOH produced hydrazone (III).Subsequent Fischer indole synthesis employing (III) and H2SO4 furnished the title indolobenzazepinone.
📌 参考资料/链接：
参考文献标题:Paullones,a series of cyclin-dependent kinase inhibitors: Synthesis,evaluation of CDK1/cyclin B inhibition,and in vitro antitumor activity
文献作者:Schultz,C.; Link,A.; Leost,M.; Zaharevitz,D.W.; Gussio,R.; Sausville,E.A.; Meijer,L.; Kunick,C.
参考来源:J Med Chem 1999,42(15),2909