新产品编号:1607821

Chemical Name: 2-[4-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-5-imino-4,5-dihydro-1,3,4-thiadiazol-2-yl]pyridine-4-carbonitrile
项目整合开发状态: Biological Testing
项目研究机构: Pfizer (Originator)
合成路线:Condensation of 2,6-dichloro-4-(trifluoromethyl)phenylhydrazine (I) with pyridine carbaldehyde (II) afforded the corresponding hydrazone (III),which was subsequently brominated to produce hydrazonoyl bromide (IV).Further treatment of (IV) with potassium thiocyanate in refluxing MeOH resulted in cyclization to yield the target thiadiazole.