新产品编号:1606239
Chemical Name: 3-[3-Ethoxy-3-oxo-1(E)-propenyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester
项目整合开发状态: Biological Testing
项目研究机构: CNRS (Originator), Sanofi-Synth閘abo (Originator)
合成路线:Ethyl 6-azaindole-3-carboxylate (I) was formylated using dichloromethyl methyl ether and AlCl3 to provide aldehyde (II).Nitrogen protection in (II) with benzenesulfonyl chloride and NaH gave sulfonyl derivative (III).Subsequent Wittig condensation of (III) with (ethoxycarbonylmethylene)triphenyl phosphorane produced the unsaturated ester (IV).Finally,removal of the benzenesulfonyl protecting group of (IV) was effected by treatment with ethanolic NaOEt.
📌 参考资料/链接：
参考文献标题:Synthesis and benzodiazepine receptor (omega receptor) affinities of 3-substituted derivatives of pyrrolo[2,3-c]pyridine-5-carboxylate,a novel class of omega1 selective ligands
文献作者:Doisy,X.; Dekhane,M.; Le Hyaric,M.; Rousseau,J.F.; Singh,S.K.; Tan,S.; Guilleminot,V.; Schoemaker,H.; Sevrin,M.; George,P.; Potier,P.; Dodd,R.H.
参考来源:Bioorg Med Chem 1999,7(5),921