新产品编号:1598329

Chemical Name: (1-Naphthyl)methylphosphonic acid 4,5,6-trimethoxy-3-oxo-1,3-dihydrobenzofuran-1-yl diester
项目整合开发状态: Preclinical
项目研究机构: Metabasis (Originator)
合成路线:Iodination of 3,4,5-trimethoxybenzyl alcohol (I) with iodine in the presence of silver trifluoroacetate gave the 2-iodobenzyl alcohol (II).Subsequent palladium-catalyzed carbonylation-lactonization reaction with (II) gave rise to phthalide (III).This was brominated using NBS to afford the 3-bromophthalide (IV).Finally,condensation of (IV) with (1-naphthyl)methylphosphonic acid (V) yielded the title bisphthalidyl phosphonate.