新产品编号:1590419
Chemical Name: N-(2-Fluoroethyl)-N'-[(4Z,7Z,10Z,13Z)-nonadeca-4,7,10,13-tetraen-1-yl]urea
项目整合开发状态: Preclinical
项目研究机构: Organix (Originator)
合成路线:Curtius rearrangement of arachidonic acid (I) in the presence of diphenyl phosphoryl azide in hot benzene gave isocyanate (II),which was coupled with methylamine to yield the title urea.
合成路线:Curtius rearrangement of arachidonic acid (I) in the presence of diphenyl phosphoryl azide in hot benzene gave isocyanate (II),which was coupled with 2-fluoroethylamine (III) to yield the title urea.
合成路线:Curtius rearrangement of arachidonic acid (I) in the presence of diphenyl phosphoryl azide in hot benzene gave isocyanate (II),which was coupled with ethanolamine (III) to yield the title urea.
📌 参考资料/链接:
参考文献标题:Unique analogues of anandamide: Arachidonyl ethers and carbamates and norarachidonyl carbamates and ureas
文献作者:Ng,E.W.; Aung,M.M.; Abood,M.E.; Martin,B.R.; Razdan,R.K.
参考来源:J Med Chem 1999,421975