新产品编号:1587255
Chemical Name: N-Butyl-2,1,3-benzoxadiazole-6-carboxamide 1-oxide
项目整合开发状态: Preclinical
项目研究机构: Universidad de Chile (Originator), Universidad de la Rep鷅lica (Originator)
合成路线:Cyclocondensation of 4-azido-3-nitrobenzoic acid (I) in boiling toluene yielded the benzoxadiazol system (II).Subsequent treatment with thionyl chloride gave acid chloride (III),which was finally condensed with n-butylamine to furnish the corresponding amide.
📌 参考资料/链接：
参考文献标题:1,2,5-Oxadiazole N-oxide derivatives and related compounds as potential antitrypanosomal drugs: Structure-activity relationships
文献作者:Cerecetto,H.; Di Maio,R.; Gonz醠ez,M.; Risso,M.; Saenz,P.; Seoane,G.; Denicola,A.; Peluffo,G.; Quijano,C.; Olea-Azar,C.
参考来源:J Med Chem 1999,42(11),1941