新产品编号:1585673
Chemical Name: 2-[4-(4-Chlorophenyl)-3-methyl-7-oxoisoxazolo[3,4-d]pyridazin-6-yl]acetic acid
项目整合开发状态: Biological Testing
项目研究机构: Istituto Chimico Farm. e Tossicol. (Originator), Universit?degli Studi di Firenze (Originator), Universit?degli Studi di Modena (Originator)
合成路线:Condensation of ketoester (I) with ethyl chloro(hydroxymino)acetate (II) provided isoxazole (III),which was cyclized to isoxazolopyridazine (IV) using hydrazine.Alkylation of (II) with ethyl bromoacetate gave ester (V),which was finally hydrolyzed with NaOH to afford the title carboxylic acid.
📌 参考资料/链接：
参考文献标题:Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors
文献作者:Costantino,L.; Rastelli,G.; Gamberini,M.C.; Giovannoni,M.P.; Dal Piaz,V.; Vianello,P.; Barlocco,D.
参考来源:J Med Chem 1999,42(11),1894
📄 详细内容
合成路线:Condensation of ketoester (I) with ethyl chloro(hydroxymino)acetate (II) provided isoxazole (III),which was cyclized to isoxazolopyridazine (IV) using hydrazine.Alkylation of (II) with ethyl bromoacetate gave ester (V),which was finally hydrolyzed with NaOH to afford the title carboxylic acid.
参考文献标题:5-Acyl-6-aryl-4-nitro-3(2H)pyridazinones and related 4-amino compounds: Synthesis and pharmacological evaluation
文献作者:Ciciani,G.; et al.
参考来源:J Pharm Sci 1991,80(4),341-348