新产品编号:1547705
Chemical Name: 6-Chloro-7-(4-methoxyphenylamino)isoquinoline-5,8-dione
项目整合开发状态: Biological Testing
项目研究机构: Ewha Womans University (Originator), Korea Res. Inst. Chem. Technol. (Originator)
合成路线:Treatment of 5-nitroisoquinoline (I) with hydroxylamine and KOH produced 5-nitro-8-aminoisoquinoline (II).Subsequent hydrogenation of (II) over Pd/C gave diamine (III),which was then oxidized to the dichloroquinone (IV) by means potassium chlorate and concentrated HCl.Finally,displacement of the 7-chloro atom of (IV) with p-anisidine (V) in refluxing EtOH yielded the title compound.
📌 参考资料/链接：
参考文献标题:Synthesis and cytotoxic activities of 6-chloro-7-arylamino-5,8-isoquinolinediones
文献作者:Ryu,C.K.; Lee,I.K.; Jung,S.H.; Lee,C.O.
参考来源:Bioorg Med Chem Lett 1999,9(8),1075
📄 详细内容
合成路线:Treatment of 5-nitroisoquinoline (I) with hydroxylamine and KOH produced 5-nitro-8-aminoisoquinoline (II).Subsequent hydrogenation of (II) over Pd/C gave diamine (III),which was then oxidized to the dichloroquinone (IV) by means potassium chlorate and concentrated HCl.Finally,displacement of the 7-chloro atom of (IV) with p-anisidine (V) in refluxing EtOH yielded the title compound.
参考文献标题:7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines
文献作者:Ryu,C.-K.; Jung,S.-H.; Lee,I.-K.; et al.
参考来源:Med Chem Res 2000,10(1),40