新产品编号:1538213

Chemical Name: 2-(7-Fluoro-4-oxo-4H-1-benzopyran-2-yl)benzoic acid
项目整合开发状态: Biological Testing
项目研究机构: Universit?degli Studi di Bologna (Originator), Universit?degli Studi di Milano (Originator), Universit?degli Studi di Padova (Originator)
合成路线:Friedel-Crafts acylation of 3-fluorophenol (I) with acetic anhydride in the presence of AlCl3 at 120 C provided 4-fluoro-2-hydroxy-acetophenone (II).Subsequent treatment of (II) with phthaloyl chloride (III) in pyridine afforded diester (IV).Heating of (IV) with K2CO3 in pyridine,followed by acidic work-up yielded the title flavone.