新产品编号:1533467

Chemical Name: 8-[4-[N-(7-Hydroxy-2,3-dihydro-1-benzofuran-2-ylmethyl)-N-propylaminobutyl]-8-azaspiro[4.5]decane-7,9-dione oxalate
项目整合开发状态: Biological Testing
项目研究机构: Servier (Originator)
合成路线:The condensation of 8-methoxy-3,4-dihydro-2H-1-benzopyran-3-amine (I) with 8-(4-bromobutyl)-8-azaspiro[4.5]decane-7,9-dione (II) by means of KI and triethylamine in ot DMF gives the secondary amine (III),which is alkylated with propyliodide and K2CO3 in hot DMF affording the tertiary amine (IV).Finally,this compound is treated with BBr3 in refluxing dichloromethane.