新产品编号:1517647
Chemical Name: 2-Hydroxy-6-(tetradecyloxy)benzoic acid
项目整合开发状态: Biological Testing
项目研究机构: R.W. Johnson (Originator)
合成路线:Fischer esterification of gamma-resorcylic acid (I) with EtOH and H2SO4 provided the ethyl ester (II).Subsequent Mitsunobu coupling of (II) with 1-tetradecanol (III) furnished ether (IV).The ethyl ester group of (IV) was finally hydrolyzed under basic conditions to yield the title carboxylic acid.
📌 参考资料/链接：
参考文献标题:6-Oxa isosteres of anacardic acids as potent inhibitors of bacterial histidine protein kinase (HPK)-mediated two-component regulatory systems
文献作者:Kanojia,R.M.; Murray,W.; Bernstein,J.; Fernandez,J.; Foleno,B.D.; Krause,H.; Lawrence,L.; Webb,G.; Barrett,J.F.
参考来源:Bioorg Med Chem Lett 1999,9(20),2947
📄 详细内容
合成路线:Fischer esterification of gamma-resorcylic acid (I) with EtOH and H2SO4 provided the ethyl ester (II).Subsequent Mitsunobu coupling of (II) with 1-tetradecanol (III) furnished ether (IV).The ethyl ester group of (IV) was finally hydrolyzed under basic conditions to yield the title carboxylic acid.
参考文献标题:6-Oxa isosteres of anacardic acids as potent inhibitors of bacterial histidine protein kinase (HPK)-mediated two-component regulatory systems
文献作者:Kanojia,R.M.; Fernandez,J.; Foleno,B.D.; Murray,W.; Benstein,J.; Barret,J.F.
参考来源:217th ACS Natl Meet (March 21 1999,Anaheim) 1999,Abst MEDI 193