新产品编号:1511319

Chemical Name: N-[N-[3-(2,3-Diphenylpropionamidomethyl)benzyl]amidino]-N'-[tetrahydrofuran-2(R)-ylmethyl]urea
项目整合开发状态: Preclinical
项目研究机构: Alanex (Originator)
合成路线:The reaction of m-xylene-alpha,alpha'-diamine (I) with N,N'-bis(tert-butoxycarbonyl)pyrazole-1-carboxamidine (II) in THF gives the protected guanidine (III),which is acylated at the free amino group with 2,3-diphenylpropionyl chloride (IV) and triethylamine in dichloromethane affording the amide (V).The condensation of (V) with tetrahydrofuran-2-ylmethylamine (VI) in refluxing THF affords the protected amidinourea (VII),which is finally treated with TFA in dichloromethane.