新产品编号:1492335

Chemical Name: 1-(2,5-Dimethoxybenzyl)-4-(4-methoxyphenyl)-2-oxo-1,2-dihydrobenzofuro[3,2-b]pyridine-3-carboxylic acid
项目整合开发状态: Biological Testing
项目研究机构: Merck KGaA (Originator)
合成路线:2-Cyanophenol (I) was condensed with 2-bromo-4'-methoxyacetophenone (II) in the presence of K2CO3 in acetone to give aminobenzofuran (III).This was acylated with trifluoroacetic anhydride,and the resulting trifluoroacetamide (IV) was alkylated with 2,5-dimethoxybenzyl chloride (V) under phase-transfer conditions to afford monobenzylated compound (VI).The benzofuro[3,2-b]pyridine nucleus was formed by acylation of the secondary amine group of (VI) with ethyl malonyl chloride (VII) to give (VIII) followed by an intramolecular Knoevenagel condensation over silica gel in refluxing CH2Cl2 to give (IX).Alkaline hydrolysis of the ester function of (IX) then provided the corresponding carboxylic acid.