新产品编号:1474933
Chemical Name: (-)-2,2-Dimethyl-5-phenyl-3-(benzamido)pentanoic acid anhydride
项目整合开发状态: Biological Testing
项目研究机构: Nippon Steel (Originator)
合成路线:The acylation of 3-amino-2,2-dimethyl-5-phenylpentanoic acid (I) with benzoyl chloride (II) in pyridine gives the corresponding amide (III),which is finally converted into the target anhydride by reaction with bromo-tris-pyrrolidino-phosphonium hexafluorophosphate (PyBroP) and triethylamine in dichloromethane.
📌 参考资料/链接：
参考文献标题:Symmetrical anhydride-type serine protease inhibitors: Structure-activity relationship studies of human chymase inhibitors
文献作者:Iijima,K.; Katada,J.; Hayashi,Y.
参考来源:Bioorg Med Chem Lett 1999,9(3),413