新产品编号:1421145
Chemical Name: 7-Chloro-6-fluoro-3-(4-methypiperazin-1-ylcarbonyl)-4(1H)-quinolinone
项目整合开发状态: Biological Testing
项目研究机构: Central Drug Research Institute (Originator)
合成路线:Title compound was synthesized by condensation of ethyl 6-fluoro-4-quinolone-3-carboxylate (I) with cyclohexylamine (II) in pyridine at 120 C under pressure.
合成路线:Title compound was synthesized by condensation of ethyl 6-fluoro-4-quinolone-3-carboxylate (I) with N-methylpiperazine (II) in pyridine at 120 C under pressure.
合成路线:Title compound was synthesized by condensation of ethyl 7-chloro-6-fluoro-4-quinolone-3-carboxylate (I) with cyclohexylamine (II) in pyridine at 120 C under pressure.
合成路线:Title compound was synthesized by condensation of ethyl 7-chloro-6-fluoro-4-quinolone-3-carboxylate (I) with N-methylpiperazine (II) in pyridine at 120 C under pressure.
📌 参考资料/链接:
参考文献标题:Synthesis and methemoglobin toxicity of the amides of 6/7 mono or disubstituted quinolone
文献作者:Srivastava,S.; Srivastava,S.K.; Shukla,A.; Chauhan,P.M.; Puri,S.K.; Bhaduri,A.P.; Pandey,V.C.
参考来源:Bioorg Med Chem Lett 1999,9(1),25