新产品编号:1406907
Chemical Name: 3-Methyl-7-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-benzopyran-2-one hydrochloride
项目整合开发状态: Biological Testing
项目研究机构: AstraZeneca (Originator)
合成路线:7-Hydroxy-3-methylcoumarin (III) was obtained by Perkin reaction of 2,4-dihydroxybenzaldehyde (I) and propionic anhydride (II) in the presence of sodium propionate in pyridine.Alkylation of N-phenylpiperazine (IV) with 1-bromo-3-chloropropane (V) and NaOH in acetone provided the chloropropyl compond (VI),which was finally condensed with coumarin (III) using NaH in DMF.
📌 参考资料/链接：
参考文献标题:Phenylpiperazine derivatives with strong affinity for 5HT1A,D2A and D3 receptors
文献作者:Ter�? C.; Santana,L.; Uriarte,E.; Fall,Y.; Unelius,L.; Tolf,B.R.
参考来源:Bioorg Med Chem Lett 1998,8(24),3567
📄 详细内容
合成路线:7-Hydroxy-3-methylcoumarin (III) was obtained by Perkin reaction of 2,4-dihydroxybenzaldehyde (I) and propionic anhydride (II) in the presence of sodium propionate in pyridine.Alkylation of N-phenylpiperazine (IV) with 1-bromo-3-chloropropane (V) and NaOH in acetone provided the chloropropyl compond (VI),which was finally condensed with coumarin (III) using NaH in DMF.
参考文献标题:Synthesis and characterization of new methylpsoralens as potential photochemotherapeutic agents
文献作者:Antonello,C.; Zagotto,G.; Mobilio,S.; Marzano,C.; Gia,O.; Uriarte,E.
参考来源:Farmaco 1994,49(4),277