新产品编号:1402161
Chemical Name: 2(S)-Amino-N-hydroxy-4-(methylsulfanyl)butanamide trifluoroacetic acid; N-Hydroxy-L-methioninamide trifluoroacetic acid
项目整合开发状态: Biological Testing
项目研究机构: ImaGene (Originator)
合成路线:N-(tert-Butoxycarbonyl)-L-methionine (I) was converted to mixed anhydride (III) upon treatment with isobutyl chloroformate (II).Subsequent condensation of (III) with hydroxylamine gave hydroxamic acid (IV).Finally,the Boc group was cleared with trifluoroacetic acid in anisole to furnish the target methionine hydroxamate).
📌 参考资料/链接:
参考文献标题:Methionine analogues as inhibitors of methionyl-tRNA synthetase
文献作者:Lee,J.; Kang,M.K.; Chun,M.W.; Jo,Y.J.; Kwak,J.H.; Kim,S.
参考来源:Bioorg Med Chem Lett 1998,8(24),3511