新产品编号:1391087
Chemical Name: 7-Methyl-3-[(2-phenylethyl)sulfanylmethyl]imidazo[1,2-a]pyridine
项目整合开发状态: Biological Testing
项目研究机构: Rega Institute for Medical Research (Originator)
合成路线:The cyclization of 4-methylpyridine-2-amine (I) with 2-bromoacetaldehyde (II) in refluxing ethanol gives 7-methylimidazo[1,2-a]pyridine (III),which by reaction with formaldehyde in refluxing acetic acid is converted into 7-methylimidazo[1,2-a]pyridin-3-ylmethanol (IV).Finally,this compound is condensed with 2-phenylethanethiol (V) in acetic acid at 100 C.
📌 参考资料/链接：
参考文献标题:Synthesis of imidazo[1,2-a]pyridines as antiviral agents
文献作者:Gueiffier,A.; Mavel,S.; Lhassani,M.; Elhakmaoui,A.; Snoeck,R.; Andrei,G.; Chavignon,O.; Teulade,J.C.; Witvrouw,M.; Balzarini,J.; De Clercq,E.; Chapat,J.P.
参考来源:J Med Chem 1998,41(25),5108