VB-5122

Chemical Name: 1-[2,6-Bis(1-pyrrolidinyl)pyrimidin-4-yl]-4-[3-chloro-5-[5-(4-pyridyl)-1H-1,2,4-triazol-3-yl]benzyl]piperazine
项目整合开发状态: Preclinical
项目研究机构: Vrije Universiteit (Originator)
合成路线:The condensation of 2,4-bis(1-pyrrolidinyl)-6-(1-piperazinyl)pyrimidine (I) with 3-(bromomethyl)-5-chlorobenzonitrile (II) gives the disubstituted piperazine derivative (III).The partial hydrolysis of the CN group of (III) with methanol/HCl yiedls the iminoether (IV),which is condensed with 4-pyridylcarbonylhydrazide (V) to afford the amidrazone (VI).Finally,this compound is cyclized by heating.