新产品编号:1274019
Chemical Name: 4-(3-Cyanophenoxy)benzoic acid
项目整合开发状态: Preclinical
项目研究机构: Kotobuki (Originator)
合成路线:By Ullmann condensation of 4-chlorobenzoic acid (I) with 3-hydroxybenzonitrile (II) by means of Cu or CuI and K2CO3 in DMF at 170 C.The same reaction can also be performed with 4-bromo- or 4-iodobenzoic acids instead of 4-chlorobenzoic acid (I).
📌 参考资料/链接：
参考文献标题:Synthesis and structure-activity relationships of substituted biaryl,biaryl ether derivatives as uricosuric agents
文献作者:Nimura,M.; et al.
参考来源:216th ACS Natl Meet (Aug.23-27,Boston) 1998,Abst MEDI 169