COBRA-0, WHI-261, DDE-261
Chemical Name: 1(R)-[5(R)-(Hydroxymethyl)tetrahydrofuran-2(R)-yl]tridecan-1-ol
项目整合开发状态: Biological Testing
项目研究机构: Parker Hughes Institute (Originator)
合成路线:The Grignard reaction of undecylmagnesium bromide (II) with epoxide (I) in ethyl ether gives benzyloxytetrahydrofuryl-dodecanol (III),which is finally debenzylated with H2 over Pd/C in ethyl acetate.
📌 参考资料/链接：
参考文献标题:Tubulin binding cpds.(COBRA)
文献作者:Mao,C.; Uckun,F.M.; Jan,S.-T.M.(Parker Hughes Institute)
参考来源:WO 0000483