D-19384, meso-1-PtSO4
Chemical Name: meso-1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine diaquaplatin(II) sulfate dihydrate
项目整合开发状态: Preclinical
项目研究机构: Asta Medica (Originator)
合成路线:The dichloroplatinum(II) complex (II) is synthesized by reacting K2PtCl4 with meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine (I) in tert-BuOH / H2O or DMF / H2O at pH 5-6 and temperature below 40 C.The corresponding sulfatoplatinum(II) complex D-19384 is obtained by addition of Ag2SO4 to a suspension of the dichloro complex (II) in H20 at 40 C.
📌 参考资料/链接：
参考文献标题:Tumor inhibitor (1,2-diphenyl-ethylendiamine)-plat
文献作者:Sch鰊enberger,H.; Von Argerer,E.; Karl,J.; Jennerwein,M.; Engel,J.(Asta Medica AG)
参考来源:DE 3604866; EP 0193055; ES 8707920; JP 1986194095; US 4730068
📄 详细内容
合成路线:The dichloroplatinum(II) complex (II) is synthesized by reacting K2PtCl4 with meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine (I) in tert-BuOH / H2O or DMF / H2O at pH 5-6 and temperature below 40 C.The corresponding sulfatoplatinum(II) complex D-19384 is obtained by addition of Ag2SO4 to a suspension of the dichloro complex (II) in H20 at 40 C.
合成路线:meso-1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine (I) is svnthesized by [3.3]sigmatropic diaza-Cope rearrangement according to the method of V鰃tle and Goldschmitt by reaction of meso-1,2-bis(2-hydroxyphenyl)ethylenediamine (IV) with 2,6-dichloro-4methoxybenzaldehyde (V) at temperature below 120 C via the corresponding aldimine (VI) and subsequent ether cleavage with boron tribromide.
参考文献标题:D-19384
文献作者:Lux,F.; Hilgard,P.; Respondek,J.M.; Karl,J.; Engel,J.; Sch鰊enberger,H.; Schumacher,W.
参考来源:Drugs Fut 1988,13(3),215
合成路线:meso-1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine (I) is svnthesized by [3.3]sigmatropic diaza-Cope rearrangement according to the method of V鰃tle and Goldschmitt by reaction of meso-1,2-bis(2-hydroxyphenyl)ethylenediamine (IV) with 2,6-dichloro-4methoxybenzaldehyde (V) at temperature below 120 C via the corresponding aldimine (VI) and subsequent ether cleavage with boron tribromide.
参考文献标题:
文献作者:V鰃tle,F.; Goldschmidt,E.
参考来源:Chem Ber 1976,1091