Tiamulin pamoate
Chemical Name: 14-Deoxy-14-[2-[2-(diethylamino)ethylthio]acetoxy]mutilin pamoate; (3aS,4R,5S,6S,8R,9R,9aR,10R)-8-[2-[2-(Diethylamino)ethylthio]acetoxy]-5-hydroxy-4,6,9,10-tetramethyl-6-vinyl-3a,9-propanoldecahydrocyclopentacycloocten-1-one 4,4'-methylenebis(3-hydroxy-2-
项目整合开发状态: Biological Testing
项目研究机构: Novartis (Originator)
合成路线:By selective tosylation of pleuromutilin (I) with tosyl chloride and triethylamine in CHCl3 giving 14-deoxy-14-tosyloxyacetoxymutiline (II),which is then treated with 2-diethylaminoethanethiol (A) in ethanol containing sodium ethoxide.
📌 参考资料/链接：
参考文献标题:Substituted 14-desoxymutilin compositions
文献作者:Egger,H.; Reinshagen,H.(Novartis AG)
参考来源:DE 2248237; FR 2157828; GB 1410505; JP 48044244; US 4278674
📄 详细内容
合成路线:By selective tosylation of pleuromutilin (I) with tosyl chloride and triethylamine in CHCl3 giving 14-deoxy-14-tosyloxyacetoxymutiline (II),which is then treated with 2-diethylaminoethanethiol (A) in ethanol containing sodium ethoxide.
参考文献标题:Tiamulin
文献作者:Casta馿r,J.; Bogan,J.A.
参考来源:Drugs Fut 1977,2(4),274
合成路线:By selective tosylation of pleuromutilin (I) with tosyl chloride and triethylamine in CHCl3 giving 14-deoxy-14-tosyloxyacetoxymutiline (II),which is then treated with 2-diethylaminoethanethiol (A) in ethanol containing sodium ethoxide.
参考文献标题:New pleuromutilin derivatives with enhanced antimicrobial avtivity.I.Synthesis
文献作者:Egger,H.; Reinshagen,H.
参考来源:J Antibiot 1976,29(9),915