ADAM-II
Chemical Name: 6,6-Bis[3-chloro-4-methoxy-5-(methoxycarbonyl)phenyl]-5-hexenoic acid methyl ester
项目整合开发状态: Biological Testing
项目研究机构: National Cancer Institute (Originator), Purdue University (Originator)
合成路线:Title compound was prepared by Wittig condensation of benzophenone (I) with the phosphorane derived from (4-methoxycarbonylbutyl)triphenyl phosphonium bromide (II) and sodium hexamethyldisilazide at -78 C.
📌 参考资料/链接：
参考文献标题:Alkenyldiarylmethane non-nucleoside HIV-1 reverse transcriptase inhibitors
文献作者:Rice,W.G.; Casimiro-Garcia,A.; Cushman,M.S.(Purdue Research Foundation; US Department of Health & Human Services)
参考来源:WO 9936384
📄 详细内容
合成路线:Title compound was prepared by Wittig condensation of benzophenone (I) with the phosphorane derived from (4-methoxycarbonylbutyl)triphenyl phosphonium bromide (II) and sodium hexamethyldisilazide at -78 C.
参考文献标题:New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors
文献作者:Cushman,M.; Casimiro-Garcia,A.; Hejchman,E.; Ruell,J.A..; Huang,M.; Schaeffer,C.A.; Williamson,K.; Rice,W.G.; Buckheit,R.W.Jr.
参考来源:J Med Chem 1998,41(12),2076