新产品编号:1177517
Chemical Name: 1-(3,3-Diphenylpropyl)-4-[4-(methylsulfonyl)benzyl]hexahydro-1,4-diazepine
项目整合开发状态: Biological Testing
项目研究机构: Teijin (Originator)
合成路线:Reaction of 3,3-diphenylpropylmethanesulfonate (I) with homopiperazine hydrochloride (II) and NaI in ethanol provides compound (III),which is finally condensed with 4-(methylsulfonyl)benzyl bromide by means of K2CO3 in acetonitrile or by means of NaI in ethanol.
📌 参考资料/链接：
参考文献标题:Diarylalkyl cyclic diamine derivs.as chemokine receptor antagonists
文献作者:Shiota,T.; Yamagami,S.; Kataoka,K.; Endo,N.; Tanaka,H.; Barnum,D.; Greene,J.; Moree,W.; Ramirez-Weinhouse,M.; Tarby,C.(Teijin Ltd.)
参考来源:EP 0914319; JP 1997309877; WO 9744329
📄 详细内容
合成路线:Reaction of 3,3-diphenylpropylmethanesulfonate (I) with homopiperazine hydrochloride (II) and NaI in ethanol provides compound (III),which is finally condensed with 4-(methylsulfonyl)benzyl bromide by means of K2CO3 in acetonitrile or by means of NaI in ethanol.
参考文献标题:Chemokine receptor antagonistic activities and structure-activity relationship of novel homopiperazine derivatives
文献作者:Shiota,T.; et al.
参考来源:19th Symp Med Chem and 8th Annu Meet Div Med Chem Jpn (Nov 17-19,Tokyo) 1999,Abst 1P-10