新产品编号:1160115

Chemical Name: 5-Methoxy-1-[4-(quinolin-2-ylmethoxy)benzyl]indazol-3-ol dihydrochloride
项目整合开发状态: Biological Testing
项目研究机构: AWD.pharma (Originator)
合成路线:Reaction of 2-bromo-5-methoxybenzoic acid (I) with hydrazine hydrate gave hydrazinobenzoic acid (II),which was cyclized to indazole (III) on heating with hydrochloric acid.Subsequent alkylation with 2-[4-(chloromethyl)phenoxymethyl]quinoline hydrochloride (IV) in the presence of sodium hydroxide in DMSO provided (V),and treatment of this with HCl in acetone furnished the target dihydrochloride.