RGH-0537
Chemical Name: (-)-(3S,14R,16R)-16-Ethyl-14-hydroxymethyl-3,4,5,6,14,15,16,17,18,19-decahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine
项目整合开发状态: Biological Testing
项目研究机构: Gedeon Richter (Originator)
合成路线:The optically active 3,16-trans-eburnamenine ester (I),a by-product in the manufacture of vinpocetine,is hydrogenated to yield the 14,15-dihydro derivative (II) having a beta-oriented carbomethoxy group.Reduction with LiAlH4 gives,with concomitant inversion of configuration at C-14,the alcohol (III),RGH-0537.
📌 参考资料/链接：
参考文献标题:Apovincaminic acid esters
文献作者:Szantay,C.; Szabo,L.; Kalaus,G.; Kreidl,J.; Czibula,L.; Visku,G.; Nemes,A.; Farkas,N.K.M.(Gedeon Richter Ltd.)
参考来源:DE 3222096; FR 2507605; GB 2102415; GB 2151629; HU 186891; JP 58043971; US 4474960
📄 详细内容
合成路线:The optically active 3,16-trans-eburnamenine ester (I),a by-product in the manufacture of vinpocetine,is hydrogenated to yield the 14,15-dihydro derivative (II) having a beta-oriented carbomethoxy group.Reduction with LiAlH4 gives,with concomitant inversion of configuration at C-14,the alcohol (III),RGH-0537.
参考文献标题:RGH-0537
文献作者:N骻r醖i,M.
参考来源:Drugs Fut 1987,12(8),775