DWA-2114
Chemical Name: 1,1-Cyclobutanedicarboxylate (2-aminomethylpyrrolidine) platinum (II) complex
项目整合开发状态: Preclinical
项目研究机构: Chugai (Originator)
合成路线:The reaction of 2 aminomethylpyrrolidine (I) with potassium tetrachloropiatinum (II) gives dichloro piatinum complex (III),which is nitrated with silver nitrate and followed by substitution with cyclobutanedicarboxylate (IV).
📌 参考资料/链接：
参考文献标题:DWA-2114
文献作者:Hoshi,A.
参考来源:Drugs Fut 1987,12(10),939
📄 详细内容
合成路线:The reaction of 2 aminomethylpyrrolidine (I) with potassium tetrachloropiatinum (II) gives dichloro piatinum complex (III),which is nitrated with silver nitrate and followed by substitution with cyclobutanedicarboxylate (IV).
参考文献标题:Synthesis and antitumor activity of platinum complexes (I)
文献作者:Morikawa,K.; Koizumi,M.; Endo,K.; Yono,T.; Mitusui,H.; Akamatsu,K.; Honda,H.
参考来源:106th Annu Meet Pharm Soc Jpn (Chiba) 1986,Abstr.4E 10-2