Chemical Name: 1-(beta-D-Arabinofuranosyl)cytosine-5'-diphosphate-rac-1-S-hexadecyl-2-O-palmitoyl-1-thioglycerol
项目整合开发状态: Biological Testing
项目研究机构: Health Research (Originator)
合成路线:Compound is obtained by reaction of phosphoric acid 2-(hexadecanoyloxy)-3-(hexadecylsulfanyl)propyl monoester (I) with 1-[5-O-[4-morpholinyl(hydroxy)phosphoryl]-beta-D-arabinofuranosyl]cytosine (II).
合成路线:Compound is obtained by reaction of phosphoric acid 2-(hexadecanoyloxy)-3-(octadecyloxy)propyl monoester (I) with 1-[5-O-[4-morpholinyl(hydroxy)phosphoryl]-beta-D-arabinofuranosyl]cytosine (II).
合成路线:Compound is obtained by reaction of phosphoric acid 2-(hexadecanoyloxy)-3-(octadecylsulfanyl)propyl monoester (I) with 1-[5-O-[4-morpholinyl(hydroxy)phosphoryl]-beta-D-arabinofuranosyl]cytosine (II).
合成路线:Compound is obtained by reaction of phosphoric acid 2-(hexadecanoyloxy)-3-(hexadecyloxy)propyl monoester (I) with 1-[5-O-[4-morpholinyl(hydroxy)phosphoryl]-beta-D-arabinofuranosyl]cytosine (II).
📄 详细内容
合成路线:Compound is obtained by reaction of phosphoric acid 2-(hexadecanoyloxy)-3-(hexadecylsulfanyl)propyl monoester (I) with 1-[5-O-[4-morpholinyl(hydroxy)phosphoryl]-beta-D-arabinofuranosyl]cytosine (II).
合成路线:Compound is obtained by reaction of phosphoric acid 2-(hexadecanoyloxy)-3-(octadecyloxy)propyl monoester (I) with 1-[5-O-[4-morpholinyl(hydroxy)phosphoryl]-beta-D-arabinofuranosyl]cytosine (II).
合成路线:Compound is obtained by reaction of phosphoric acid 2-(hexadecanoyloxy)-3-(octadecylsulfanyl)propyl monoester (I) with 1-[5-O-[4-morpholinyl(hydroxy)phosphoryl]-beta-D-arabinofuranosyl]cytosine (II).
合成路线:Compound is obtained by reaction of phosphoric acid 2-(hexadecanoyloxy)-3-(hexadecyloxy)propyl monoester (I) with 1-[5-O-[4-morpholinyl(hydroxy)phosphoryl]-beta-D-arabinofuranosyl]cytosine (II).
参考文献标题:Nucleoside conjugates.7.Synthesis and antitumor activity of 1-beta-D-arabinofuranosylcytosine conjugates of ether lipids
文献作者:Hong,C.I.; An,S.H.; Buchheit,D.J.; Nechaev,A.; Kirisits,A.J.; West,C.R.; Berdel,W.E.
参考来源:J Med Chem 1986,29(10),2038
合成路线:Compound is obtained by reaction of phosphoric acid 2-(hexadecanoyloxy)-3-(hexadecylsulfanyl)propyl monoester (I) with 1-[5-O-[4-morpholinyl(hydroxy)phosphoryl]-beta-D-arabinofuranosyl]cytosine (II).
合成路线:Compound is obtained by reaction of phosphoric acid 2-(hexadecanoyloxy)-3-(octadecyloxy)propyl monoester (I) with 1-[5-O-[4-morpholinyl(hydroxy)phosphoryl]-beta-D-arabinofuranosyl]cytosine (II).
合成路线:Compound is obtained by reaction of phosphoric acid 2-(hexadecanoyloxy)-3-(octadecylsulfanyl)propyl monoester (I) with 1-[5-O-[4-morpholinyl(hydroxy)phosphoryl]-beta-D-arabinofuranosyl]cytosine (II).
合成路线:Compound is obtained by reaction of phosphoric acid 2-(hexadecanoyloxy)-3-(hexadecyloxy)propyl monoester (I) with 1-[5-O-[4-morpholinyl(hydroxy)phosphoryl]-beta-D-arabinofuranosyl]cytosine (II).
参考文献标题:Nucleoside conjugates.14.Synthesis and antitumor activity of 1-beta-D-arabinofuranosylcytosine conjugates of ether lipids with improved water solubility
文献作者:West,C.R.; Buchheit,D.J.; Kirisits,A.J.; Hong,C.I.; Nechaev,A.
参考来源:J Med Chem 1995,38(10),1629-34
合成路线:Compound is obtained by reaction of phosphoric acid 2-(hexadecanoyloxy)-3-(hexadecylsulfanyl)propyl monoester (I) with 1-[5-O-[4-morpholinyl(hydroxy)phosphoryl]-beta-D-arabinofuranosyl]cytosine (II).
合成路线:Compound is obtained by reaction of phosphoric acid 2-(hexadecanoyloxy)-3-(octadecyloxy)propyl monoester (I) with 1-[5-O-[4-morpholinyl(hydroxy)phosphoryl]-beta-D-arabinofuranosyl]cytosine (II).
合成路线:Compound is obtained by reaction of phosphoric acid 2-(hexadecanoyloxy)-3-(octadecylsulfanyl)propyl monoester (I) with 1-[5-O-[4-morpholinyl(hydroxy)phosphoryl]-beta-D-arabinofuranosyl]cytosine (II).
合成路线:Compound is obtained by reaction of phosphoric acid 2-(hexadecanoyloxy)-3-(hexadecyloxy)propyl monoester (I) with 1-[5-O-[4-morpholinyl(hydroxy)phosphoryl]-beta-D-arabinofuranosyl]cytosine (II).
参考文献标题:ARA-C conjugates of ether and thioether phospholipids
文献作者:Hong,C.I.
参考来源:Drugs Fut 1990,15(3),245