新产品编号:1155369
Chemical Name: N-(2-Isopropoxybenzyl)-1,6-naphthyridine-2-carboxamide
项目整合开发状态: Biological Testing
项目研究机构: Shire BioChem (Originator)
合成路线:The condensation of 1,6-naphthyridine-2-carboxylic acid (I) with 2-isopropoxybenzylamine (II) by means of EDC and HOBT in DMF yields the target compound.
合成路线:The bromination of 1,6-naphthyridine-2-carboxylic acid (I) with Br2 in acetic acid gives the 8-bromo derivative (II),which is condensed with 2-isopropoxybenzylamine (III) by means of EDC and HOBT in DMF yielding the corresponding amide (IV).Finally,this compound is vinylated with CH2 = CH-SnBu3 and PdCl2(PPh3)2 in DMF.
合成路线:The bromination of 1,6-naphthyridine-2-carboxylic acid (I) with Br2 in acetic acid gives the 8-bromo derivative (II),which is condensed with 2-isopropoxybenzylamine (III) by means of EDC and HOBT in DMF yielding the corresponding amide (IV).Finally,this compound is methylated with Sn(CH3)4 and PdCl2(PPh3)2 in DMF.
📌 参考资料/链接：
参考文献标题:Discovery of 1,6-naphthyridines as a novel class of potent and selective human cytomegalovirus inhibitors
文献作者:Chan,L.; Jin,H.; Stefanac,T.; Lavall�? J.F.; Falardeau,G.; Wang,W.; B閐ard,J.; May,S.; Yuen,L.
参考来源:J Med Chem 1999,42(16),3023