SRA-880, NVP-SRA-880

Chemical Name: 1-[(3R,4aR,10aR)-6-Methoxy-1-methyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-3-yl)-1-[4-(4-nitrophenyl)piperazin-1-yl]methanone malonate
项目整合开发状态: Preclinical
项目研究机构: Novartis (Originator)
合成路线:The benzoquinoline carboxylate ester (I) is hydrolyzed with NaOH to produce the sodium carboxylate salt (II).Activation of (II) with propane-phosphonic anhydride,followed by coupling with N-(4-nitrophenyl)piperazine (III) furnishes the corresponding amide.