新产品编号:1104745
Chemical Name: [2aR-[2aalpha,4beta,4abeta,6beta,9alpha(2R,3S),11beta,12alpha,12aalpha,12balpha]]-12b-Acetoxy-12-benzoyloxy-4,6,11-trihydroxy-9-[2-hydroxy-4,4-dimethyl-3-(2-thienylcarboxamido)pentanoyloxy]-4a,8,13,13-tetramethyl-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahyd
项目整合开发状态: Biological Testing
项目研究机构: University of Kansas (Originator)
合成路线:Amine (I) was acylated with 2-thiophenecarbonyl chloride (II) in a mixture of ethyl acetate and a saturated solution of NaHCO3 to give amide (III).Then,removal of both trichloroethoxycarbonyl protecting groups was effected by treatment with zinc dust in methanol and acetic acid to provide the title compound.
📌 参考资料/链接:
参考文献标题:Butitaxel analogues: Synthesis and structure-activity relationships
文献作者:Ali,S.M.; Hoemann,M.Z..; Aube,J.; Georg,G.I.; Mitscher,L.A.; Jayasinghe,L.R.
参考来源:J Med Chem 1997,40(2),236-241