Pyrextramine
Chemical Name: 2,2'-Dithiobis(ethane-2,1-diyl)bis(imino)bis(hexane-6,1-diyl)bis(imino)bis(methylene)bis(1H-pyrrole) tetraoxalate
项目整合开发状态: Biological Testing
项目研究机构: Universit?degli Studi di Camerino (Originator)
合成路线:N1,N1'-Dithiobis(ethane-2,1-diyl)bis(hexane-1,6-diamine) (II) is prepared starting from 6-aminohexylcyste amine (I) by potassium ferricyanide oxidation.The condensation of (II) with pyrrol 2-carboxaldehyde and subsequent reduction with NaHB4 of the resulting Schitf base gives (III),which is crvstallized as tetraoxatate.
📌 参考资料/链接：
参考文献标题:Pyrextramine
文献作者:Brasili,L.
参考来源:Drugs Fut 1986,11(1),32
📄 详细内容
合成路线:N1,N1'-Dithiobis(ethane-2,1-diyl)bis(hexane-1,6-diamine) (II) is prepared starting from 6-aminohexylcyste amine (I) by potassium ferricyanide oxidation.The condensation of (II) with pyrrol 2-carboxaldehyde and subsequent reduction with NaHB4 of the resulting Schitf base gives (III),which is crvstallized as tetraoxatate.
参考文献标题:Structure-activity relationships among benextramine-related tetraamine disulfides at peripheral alpha-adrenoreceptors
文献作者:Angeli,P.; Brasili,L.; Brancia,E.; Giardina,.D.; Quaglia,W.; Melchiorre,C.
参考来源:J Med Chem 1985,28(11),1643